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. 2019 Aug 29;47:329–340. doi: 10.1016/j.ebiom.2019.08.045

Fig. 6.

Fig. 6

cTnImAb1 induces cardiac dysfunction and pathological changes in mouse heart.

a & b. Representative images of echocardiography (a) and screen shots of catheterization (b) showing decreased cardiac function in mice of the cTnImAb1 group compared with the mouse IgG and cTnTmAb groups.

c. Representative images of hematoxylin and eosin (H&E) staining showing epicardial calcified plaque formation in the mouse hearts of the cTnImAb1 group, which were not seen in those of the mouse IgG and cTnTmAb groups. Bar = 50 μm.

d. Representative images of Masson's Trichrome staining showing interstitial collagen deposition in the mouse hearts of cTnImAb1 group, which were not seen in those of the mouse IgG and cTnTmAb groups. Bar = 50 μm.

e & f. Representative images of TUNEL staining (e) and quantification (f) in the mouse hearts of the cTnImAb1 group compared with that in the mouse IgG and cTnTmAb groups. Bar = 10 μm. *p = .000 (ANOVA analysis).