Fig. 2.

Salsalate treatment slowed progression of polycystic kidney disease in iKsp-Pkd1^del mice. (a) Only treatment with salsalate (SAL) or metformin plus salsalate (MET+SAL) was associated with a significant improvement in kidney survival. Only treatment with salsalate or metformin plus salsalate was associated with a significant reduction in (b) the ratio of two-kidney weight to body weight (2KW/BW) and (c) cystic index. There was no difference between treatment with MET+SAL and SAL suggesting the therapeutic effect of the former treatment group was likely due to salsalate alone. (d) Representative histological kidney sections (i.e. the median) from different study groups. NS denotes not significant. Data presented as mean ± SEM; WT (n = 8), untreated (n = 26), SAL (n = 21), MET (n = 19), MET+SAL (n = 20).