Fig. 2.

Relative ADCC among transmission groups.

Results of the competition RFADCC assay for passively acquired ADCC in 71 infant plasma samples (a-c) and maternal ADCC in 71 corresponding maternal plasma samples (d-f). Relative ADCC in the presence of A32-LALA (a, d), C11-LALA (b, e), or 17b-LALA (d, f) is shown for HIV-exposed uninfected infants (HEU) compared to HIV-infected (HIV+) infants or non-transmitting (NT) compared to transmitting (T) mothers. Relative ADCC was compared between the infection or transmission groups by a Mann-Whitney U test. Statistical significance was defined as p < 0·05 (*). Error bars represent median + interquartile range. Results are averaged from two biological replicates. Negative values were treated as zeros. Data from individual biological replicates from seven maternal samples and six infant samples that were below the limit of detection were excluded from the analysis as described in the Materials and Methods.