Fig. 3.
Effect of Cluster A-specific ADCC on HIV-infected infant survival.
a-c: Kaplan-Meier survival curves between infants (N = 20) that had passively-acquired cluster A CD4i epitope-specific ADCC at/above the HIV-infected infant cohort median (blue lines) or below the HIV-infected infant cohort median (red lines) were compared by a log-rank test for A32-like ADCC (a), C11-like ADCC (b), or total cluster A-specific ADCC (sum of A32-like ADCC + C11-like ADCC, c). d-f: Kaplan-Meier survival curves between infants whose mothers (N = 21) had maternal cluster A CD4i epitope-specific ADCC at/above the transmitting mothers cohort median (blue lines) or below the transmitting mothers cohort median (red lines) were compared by a log-rank test for A32-like ADCC (d), C11-like ADCC (e), or total cluster A-specific ADCC (A32-like ADCC + C11-like ADCC, f). Χ2 values and p-values are shown. The x-axis shows months survival post infection (PI). The association of passively-acquired or maternal cluster A CD4i epitope-specific ADCC with risk of HIV+ infant mortality was measured by a Cox-proportional hazards model. Hazard ratios (HR), 95% confidence intervals (CI), and p-values are shown on the graphs. Statistical significance was defined as p < 0·05 (*). Cumulative (cum.) number of infants at-risk or censored by the end of each month on the x-axis are shown in the tables. Data from individual biological replicates from one maternal sample and one infant sample that were below the limit of detection were excluded from the analysis as described in the Materials and Methods. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)