Fig. 2.

Production of cytokines, chemokines and growth factors (CCGFs) in leprosy patients and household contacts compared to endemic controls. 60 CCGFs were detected in whole blood assay (WBA) supernatant of multibacillary (MB) and paucibacillary (PB) leprosy patients, household contacts (HC) and endemic controls (EC). (a) Volcano plots show the log2 fold change compared to EC (x-axis) and the -log10 (p-value) (y-axis) in unstimulated WBA supernatant (Medium; left column), in response to M.leprae whole cell sonicate (WCS; middle column) and two specific M.leprae proteins (Mlep; ML0840, ML2478; right column). The markers in either of the three groups with both a log2 fold change of 1 (−1) and a p-value <0,05 or markers with a p-value <0,001 are indicated (P-value <0,05 = red dot, log2 fold change of 1(−1) = orange dot, P-value <0,05 & log2 fold change of 1(−1) = green dot). (b) Summary of the markers indicated in the volcano plots per stimulus (Medium = left, WCS = middle and Mlep = right). Radar plots show the log2 FC of the markers indicated in the volcano plots for MB (orange), PB (blue) and HC (green) compared to the levels in EC. Dotted lines indicated a log2 FC of 1. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)