Fig. 3.

Biomarkers validated by ELISA in whole blood assay supernatant and plasma of leprosy patients. Markers showing significant areas under the curve (AUC) for multibacillary (MB; orange) and/or paucibacillary (PB; blue) leprosy patients in unstimulated whole blood assay (WBA) supernatant (med), in response to M.leprae whole cell sonicate (WCS) and two specific M.leprae proteins (Mlep) (A) or plasma samples (B). Biomarkers levels were compared to those of endemic controls. Values for AUC can range from 0.5 to 1, the dotted line indicates an AUC of 0.7. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)