Fig. 7.

C3 deposition in glomeruli of mice with nephrotoxic serum-induced glomerulonephritis decreased when treated with a B1 receptor antagonist.

Mice with nephrotoxic serum-induced glomerulonephritis were left untreated (n = 3) or treated with the oral B1R antagonist SSR240612 (n = 5). Renal tissues were stained for C3 and the degree of intensity was calculated as per Table 2. Significantly more C3 deposition was seen in mice given vehicle, compared to mice treated with the B1R-antagonist, *: P < 0·05. The bar represents the median.