Fig. 7.

Regression model with regression line is shown in (a) single MSC injection treatment, (b) multiple MSC injections treatment (linear regression), and (c) multiple MSC injections treatment (quadratic regression). The size of the dot is proportional to number of injections. The dashed lines in (a, b, and c) represent the 95% CIs. The red line represents the trend of interactions between dosage of MSC and normalised difference in clinical score changes. The size of the dot is proportional to the weighting given to the study and the detailed weighting of each study could be found in Fig. 1. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)