Fig. 1.

Skin localisation of the proteins injected into macaques. rhMOG or anti-DC-ASGPR-MOG conjugated to AF488 were injected intradermally and a skin biopsy of the injection site was analysed 4 h later by IHC. a) Detection of rhMOG in CD1a⁺ cells close to the epidermis. b) Co-localisation of anti-DC-ASGPR-MOG with CD163⁺ dermal cells. Nuclei were stained with 4,6 diamidino-2, phenylindole (DAPI) and the tissues analysed by confocal microscopy. Images are representative of (n > 20) MOG⁺ cells. See Supplemental fig. 1 for further details.