Fig. 6.

Integrative analysis for multi-block data in amyloid (+) and amyloid (−) asymptomatic individuals at-risk for AD using sparse partial least squares-discriminant analysis (sPLS-DA). a: PCA for the metabolomics block (green circles amyloid (−) individuals, red triangles amyloid (+) individuals). Percentages of the variance for the two axis are indicated in parenthesis; b: List of metabolites for the three first components with their corresponding loading plots indicating the most relevant metabolites. Each graph represents one of the components and the weight of metabolites; c: PCA for the lipidomics block (green circles amyloid (−) individuals, red triangles amyloid (+) individuals. Percentages of the variance for the two axis are indicated in parenthesis); d: List of lipids for the three first components with their corresponding loading plots indicating the most relevant lipids. Each graph represents one of the components and the weight of lipids; e: PCA for the transcriptomics block (green circles amyloid (−) individuals, red triangles amyloid (+) individuals). Percentages of the variance for the two axis are indicated in parenthesis; f: List of transcripts for the three first components with their corresponding loading plots indicating the most relevant transcripts. Each graph represents one of the components and the weight of transcripts. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)