Fig. 7.

Multi-omics signature of amyloid positivity in asymptomatic individuals at-risk for AD by grouping block-wise sparse components in a super-block. a: Graphic representation of the common space associated with the two superscores corresponding to the two first principal components combining the top omics features (green circles amyloid (−) individuals, red triangles amyloid (+) individuals); b: Variable factor map generated by the two superscores (metabolic variables in blue, genes in green and lipids in dark red). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)