Fig. 7.

Silencing Nwd1 reduces acute seizure severity during KA-induced SE.

(a) A mouse with Racine's stage VI seizure activity showing severe generalized tonic-clonic seizures. (b) A graph showing that the latency of SE onset was prolonged during SE for AAV-Nwd1-shRNA-injected mice compared to control and AAV-GFP-injected mice (n = 6 per group; *P = .0391). (c) A graph showing that, compared to control mice, AAV-Nwd1-shRNA-injected mice exhibited acute seizures of a shorter duration (n = 6 per group; *P = .0464). (d) A graph shows showing that there was no difference in the average behaviour seizure score among all groups (n = 6 per group). The error bars indicate the SEM (*P < 0.05; N.S. represents no significance; ANOVA followed by Tukey's test).