Table 2.
Summary of mutations occurring in the Tci-mptl-1 gene in seven different populations of T. circumcincta.
| T. circumcincta Population | MPTL Resistance Status | Tci-mptl-1 Product (bp) | Summary of Mutation | GenBank Accession Number |
|---|---|---|---|---|
| MTci2 | Susceptible | 1716 | Full-length CDS | MK871751 |
| MTci5 | Susceptible | 1716 | Full-length CDS | MK871752 |
| MTci7 | Susceptible | 1716 | Full-length CDS | MK871753 |
| MTci7_Alt | Susceptible | 357 | Transversion in exon 5 from T to A that leads to the introduction of a premature stop codon which truncates the gene leading to loss of all 4 transmembrane domains and regions conserved between nAChR α subunits | MK871754 |
| MTci2-11 | Resistant | 1716 | Full-length CDS | MK871755 |
| MTci7-12 | Resistant | 1716 | Full-length CDS | MK871756 |
| MTci7-12_Alt | Resistant | 357 | Transversion in exon 5 from T to A that leads to the introduction of a premature stop codon which truncates the gene leading to loss of all 4 transmembrane domains and regions conserved between nAChR α subunits | MK871757 |
| MTci5-13 | Resistant | 1716 | Full-length CDS | MK871758 |
| MTci5-13_Alt | Resistant | 954 | Insertion of 29 bp in exon 10 introduces a premature stop codon leading to the loss of exons 10 to 15 and transmembrane domain 4 | MK871759 |
| MFie18_Post | Resistant | 1716 | Full-length CDS | MK871760 |
| MFie18-Post_Alt | Resistant | 1701 | In-frame deletion of 15 bp leading to a truncated gene | MK871761 |