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. 2019 Aug 14;18:166–182. doi: 10.1016/j.omtn.2019.08.005

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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DNA Methylation of LAMA3 Leads to Its Low Expression in Lung Adenocarcinoma

(A) CpG islands in the LAMA3 promoter region. (B) The methylation of LAMA3 in H1650 cells examined by MSP. (C) The methylation of LAMA3 methylation in H1650 cells after 5-Aza treatment examined by MSP. (D) mRNA expression of LAMA3 in the H1650 cell line after 5-Aza treatment examined by qRT-PCR. (E) Western blot analysis of LAMA3 protein in the H1650 cell line after 5-Aza treatment. (F) Methylation of LAMA3 in BEAS-2B and other lung adenocarcinoma cell lines analyzed using MSP. The statistical values were measurement data, which were expressed as mean ± SD and compared with t test; *p < 0.05; **p < 0.01; and ***p < 0.001 versus BEAS-2B. The experiment was performed in triplicate.