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. 2019 Aug 14;18:166–182. doi: 10.1016/j.omtn.2019.08.005

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Inhibition of LAMA3 Promoter Methylation Hinders the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells

(A) The protein expression of LAMA3 in H1650 cells and H1299 cells after the addition of 5-Aza (5 μM) examined by western blot analysis. (B) Proliferation of H1650 cells and H1299 cells after the addition of 5-Aza (5 μM) detected using MTT assay. (C) Migration of H1650 cells and H1299 cells after the addition of 5-Aza (5 μM) examined by scratch assay. (D) Invasion of H1650 cells and H1299 cells after the addition of 5-Aza (5 μM) examined by Transwell assay. (E) Western blot analysis of protein expression of invasion-related markers (MMP2 and MMP9) and EMT-related makers (N-cadherin, Vimentin, and E-cadherin) in H1650 cells and H1299 cells. The experiment was performed in triplicate. The statistical values were measurement data, which were expressed as mean ± SD and compared with one-way ANOVA; *p < 0.05; **p < 0.01; and ***p < 0.001 compared with cells served as control and NC or the cells that served as NC treated with LAMA3.