Fig. 10.

Comparison of AUC of activity (Act) during light and dark phase. To evaluate the performance of Act to determine distress the area under the curve (AUC), the 95% confidence interval (CI) and the P-value (p) were assessed by performing receiver operating characteristic curve (ROC) analysis on data from mice before (−1) and after tumour cell injection (0), during 3–12 h light phase (A) and 12 h dark phase (B).