Table 4.

Data analysis for distress parameter during tumor progression (n = 7).

			Days before/after carcinoma cell injection (CI)
			−1	4	18	34
Fig.	Distress parameter
5A	Distress-score	Mean ± SD	0.00 0.00	0.00 0.00	0.00 0.00	0.00 0.00
5B	Burrowing [g]	Mean ± SD	174.40 41.99	185.57 21.57	165.14 44.09	140.29 50.41
5C	Body weight change	Mean ± SD	−3.36 1.75	−2.24 1.97	−0.41a 2.01	0.48a 2.28
5D	Nesting-score	Mean ± SD	4.8 0.42	4.86 0.69	5.0 0.58	4.14 1.21
5E	HR [bpm]	Mean ± SD	479.09 23.19	483.89 53.11	475.77 15.43	485.04 35.92
5F	Act [c/min]	Mean ± SD	3.91 1.12	4.20 1.27	4.67 1.01	4.43 0.92
5G	BT [°C]	Mean ± SD	36.69 0.20	36.66 0.24	36.81 0.17	36.64 0.17
5H	FCMs [ng/g]	Mean ± SD	1220.90 579.03	1097.52 480.24	1038.54 428.81	1003.62 534.43

^aP < 0.05 compared to day −1.