Figure 5.

circFBXW7 and FBXW7 Act as ceRNAs in TNBC through the Regulation of miR-197-3p

(A) Enrichment of circFBXW7, FBXW7, and miR-197-3p on Ago2, as assessed by a RIP assay. (B) The enrichment of Ago2 on circFBXW7 was decreased, while FBXW7 expression was increased after knockdown of circFBXW7. (C) Silencing FBXW7 reduced the relative enrichment of Ago2 on FBXW7 and increased the abundance of circFBXW7. (D) Knockdown of circFBXW7 resulted in a reduction in FBXW7 expression, which was reversed by miR-197-3p inhibitors. (E) Spearman correlation analysis showed that circFBXW7 expression was positively correlated with FBXW7 expression in 473 TNBC samples (r = 0.568, p < 0.001). *p < 0.05, **p < 0.01. SD is shown as error bars.