Table 2.
Univariate and Multivariate Cox Regression Analysis of circFBXW7 and Survival in Patients with Breast Cancer
| Parameter | Univariate Analysis |
Multivariate Analysis |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p Value | HR | 95% CI | p Value | |
| Age (>50 versus ≤50 years) | 0.976 | 0.653–1.458 | 0.904 | NA | ||
| TNBC (yes versus no) | 1.214 | 0.796–1.851 | 0.368 | NA | ||
| Histological grade (G3 versus G1-2) | 1.722 | 1.097–2.702 | 0.018* | NA | ||
| Tumor size (>2.0 cm versus ≤2.0 cm) | 1.934 | 1.115–3.356 | 0.019* | 1.504 | 0.845–2.674 | 0.165 |
| Lymph node status (positive versus negative) | 1.978 | 1.269–3.081 | 0.003* | 1.468 | 0.913–2.361 | 0.113 |
| TNM stage (III-IV versus I-II) | 2.342 | 1.560–3.516 | 0.001* | 1.779 | 1.143–2.769 | 0.011* |
| circFBXW7 expression (high versus low) | 0.189 | 0.105–0.339 | 0.001* | 0.215 | 0.119–0.387 | 0.001* |
| FBXW7 expression (high versus low) | 0.314 | 0.193–0.509 | 0.001* | 0.349 | 0.212–0.574 | 0.001* |
NA, not analyzed; *p < 0.05, statistically significant.