Table 1.
Oligonucleotides Used in This Study
| Substance | Specifications |
|---|---|
| miRNA132_Cy5 | (Cy5)-(NHC6)-mU-ps-mA-ps-mA-ps-mC-ps-mA-ps-mG-ps-mU-ps-mC-ps-mU-ps-mA-ps-mC-ps-mA-ps-mG-ps-mC-ps-mC-ps-mA-ps-mU-ps-mG-ps-mG-ps-mU-ps-mC-ps-mG; maverage = 7821.4 Da ± 0.05%; ε = 228400 L/mol*cm; purity > 85%; AXO LABS |
| miRNA24_Cy5 | (Cy5)-(TEG)-mU-ps-mG-ps-mG-ps-mC-ps-mU-ps-mC-ps-mA-ps-mG-ps-mU-ps-mU-ps-mC-ps-mA-ps-mG-ps-mC-ps-mA-ps-mG-ps-mG-ps-mA-ps-mA-ps-mC-ps-mA-ps-mG; Eurogentec Deutschland |
| OMeScr | mA-ps-mC-ps-mG-ps-mU-ps-mC-ps-mU-ps-mA-ps-mU-ps-mA-ps-mC-ps-mG-ps-mC-ps-mC-ps-mC-ps-mA; maverage = 5130.2 Da ± 0.05%; ε = 145500 L/mol*cm; purity > 85%; AXO LABS |
| OMe132_S1 | mA-ps-mU-ps-mG-ps-mG-ps-mC-ps-mU-ps-mG-ps-mU-ps-mA-ps-mG-ps-mA-ps-mC-ps-mU-ps-mG-ps-mU-ps-mU; purity > 85%; AXO LABS |
| OMe132_S2 | mA-ps-mT-ps-mG-ps-mG-ps-mC-ps-mT-ps-mG-ps-mT-ps-mA-ps-mG-ps-mA-ps-mC-ps-mT-ps-mG-ps-mT-ps-mT; purity > 85%; AXO LABS |
| OMe132_S3 | m(5-MeC)-ps-mT-ps-mG-ps-m(5-MeC)-ps-mT-ps-mG-ps-mA-ps-mA-ps-m(5-MeC)-ps-mT-ps-mG-ps-mA-ps-mG-ps-m(5-MeC)-ps-m(5-MeC); purity > 85%; AXO LABS |
| OMe132_S4 | m(2-aminoA)-ps-mU-ps-mG-ps-mG-ps-mC-ps-mU-ps-mG-ps-mU-ps-m(2-aminoA)-ps-mG-ps-m(2-aminoA)-ps-mC-ps-mU-ps-mG-ps-mU-ps-mU; purity > 85%; AXO LABS |
| OMe132_S5 | m(2-aminoA)-ps-mT-ps-mG-ps-mG-ps-m(5-MeC)-ps-mT-ps-mG-ps-mT-ps-m(2-aminoA)-ps-mG-ps-m(2-aminoA)-ps-m(5-MeC)-ps-mT-ps-mG-ps-mT-ps-mT; purity > 85%; AXO LABS |
| OMe24 | mC-ps-mT-ps-mG-ps-mC-ps-mT-ps-mG-ps-mA-ps-mA-ps-mC-ps-mT-ps-mG-ps-mA-ps-mG-ps-mC-ps-mC; Eurogentec Deutschland |
| OMe24_1 | mC-ps-mU-ps-mG-ps-mC-ps-mU-ps-mG-ps-mA-ps-mA-ps-mC-ps-mU-ps-mG-ps-mA-ps-mG-ps-mC-ps-mC; Eurogentec Deutschland |
| OMe24_2 | m(5-MeC)-ps-mT-ps-mG-ps-m(5-MeC)-ps-mT-ps-mG-ps-mA-ps-mA-ps-m(5-MeC)-ps-mT-ps-mG-ps-mA-ps-mG-ps-m(5-MeC)-ps-m(5-MeC); Eurogentec Deutschland |
| OMe24_3 | mC-ps-mT-ps-mG-ps-mC-ps-mT-ps-mG-ps-m(2-aminoA)-ps-m(2-aminoA)-ps-mC-ps-mT-ps-mG-ps- m(2-aminoA)-ps-mG-ps-mC-ps-mC; Eurogentec Deutschland |
| OMe24_4 | m(5-MeC)-ps-mU-ps-mG-ps-m(5-MeC)-ps-mU-ps-mG-ps-mA-ps-mA-ps-m(5-MeC)-ps-mU-ps-mG-ps-mA-ps-mG-ps-m(5-MeC)-ps-m(5-MeC); Eurogentec Deutschland |
| OMe24_5 | mC-ps-mU-ps-mG-ps-mC-ps-mU-ps-mG-ps-m(2-aminoA)-ps-m(2-aminoA)-ps-mC-ps-mU-ps-mG-ps-m(2-aminoA)-ps-mG-ps-mC-ps-mC; Eurogentec Deutschland |
| OMe24_6 | m(5-MeC)-ps-mT-ps-mG-ps-m(5-MeC)-ps-mT-ps-mG-ps-m(2-aminoA)-ps-m(2-aminoA)-ps-m(5-MeC)-ps-mT-ps-mG-ps-m(2-aminoA)-ps-mG-ps-m(5-MeC)-ps-m(5-MeC); Eurogentec Deutschland |
| OMe24_7 | m(5-MeC)-ps-mU-ps-mG-ps-m(5-MeC)-ps-mU-ps-mG-ps-m(2-aminoA)-ps-m(2-aminoA)-ps-m(5-MeC)-ps-mU-ps-mG-ps-m(2-aminoA)-ps-mG-ps-m(5-MeC)-ps-m(5-MeC); Eurogentec Deutschland |
| OMe24_8 | m(5-MeC)-ps-mT-ps-mG-ps-mC-ps-mT-ps-mG-ps-mA-ps-mA-ps-mC-ps-mT-ps-mG-ps-mA-ps-mG-ps-mC-ps-m(5-MeC); Eurogentec Deutschland |
| OMe24_9 | m(5-MeC)-ps-mU-ps-mG-ps-mC-ps-mU-ps-mG-ps-mA-ps-mA-ps-mC-ps-mU-ps-mG-ps-mA-ps-mG-ps-mC-ps-m(5-MeC); Eurogentec Deutschland |
| OMe24_10 | mC-ps-mT-ps-m(2-aminoA)-ps-mC-ps-mT-ps-m(2-aminoA)-ps-mA-ps-mA-ps-mC-ps-mT-ps-m(2-aminoA)-ps-mA-ps-m(2-aminoA)-ps-mC-ps-mC; Eurogentec Deutschland |
| OMe24_11 | m(2-aminoA)-ps-mT-ps-mG-ps-m(2-aminoA)-ps-mT-ps-mG-ps-mA-ps-mA-ps-m(2-aminoA)-ps-mT-ps-mG-ps-mA-ps-mG-ps-m(2-aminoA)-ps-m(2-aminoA); Eurogentec Deutschland |
Nucleobases were modified as described: mC, 2′-O-methyl-cytosine; mT, 2′-O-methyl-thymine; mA, 2′-O-methyl-adenosine; mG, 2′-O-methyl-guanine; mU, 2′-O-methyl-uracile; ps, phosphorothioate; m(5-MeC), 2′-O-methyl-(5-methylcytosine); m(2-aminoA), 2′-O-methyl-(2-aminoadenine).