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. 2019 Sep 9;11:13–29. doi: 10.1016/j.ijpddr.2019.09.001

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© 2019 Published by Elsevier Ltd on behalf of Australian Society for Parasitology.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — Transcriptomic analysis of differentially expressed genes visualized in Interaction plots using the UpSet method. Panel A.C. elegans CB3474 ben-1(e1880)III genes significantly (adjusted p value of less than 0.01) up-regulated greater than 2 fold to each of the benzimidazoles tested. Mebendazole (MBZ), albendazole (ABZ), thiabendazole (TBZ), oxfendazole (OxBZ) and fenbendazole (FBZ). Horizontal histogram to the left of the drug labels represent the total number of genes significantly up-regulated greater than 2 fold to each drug, vertical histogram to the right represents each sub-set of significantly up-regulated genes specific to each drug combination represented by filled circles. Panel B. Interaction Plot of C. elegans CB3474 ben-1(e1880)III genes significantly (adjusted p value < 0.01) down-regulated greater than 2 fold to each of the benzimidazoles tested. Mebendazole (MBZ), albendazole (ABZ), thiabendazole (TBZ), oxfendazole (OxBZ) and fenbendazole (FBZ). Transcriptomic analysis of differentially expressed genes visualized with the UpSet method.