. 2019 Sep 9;11:13–29. doi: 10.1016/j.ijpddr.2019.09.001

Table 1.

Summary of metabolites produced by C. elegans CB3474 ben-1(e1880)III and H. contortus drug sensitive MHco3(ISE) as determined by LC-MS/MS analysis shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4. C. elegans were cultured with each benzimidazole drug at 56.5 μM for 3 days in axenic culture. H. contortus adult worms were cultured in RPMI-1640 plus supplements with 10 μM of each benzimidazole for 16 h at 38 °C (10% CO₂).

C. elegans metabolites				H. contortus metabolites
Parental	Primary product	Secondary product	Tertiary product	Primary product	Secondary product	Tertiary product
ABZ	ABZ+hexose	ABZ+O^a		ABZ+O	ABZ+hexose^a
MBZ	MBZ+hexose+2H	MBZ+2H	MBZ+hexose^a	MBZ+hexose+2H	MBZ+2H	MBZ+hexose^a
FBZ	FBZ+hexose	FBZ+O+hexose+H^a		FBZ+hexose^a	Not found
TBZ	TBZ+O+hexose+H^a			Not found
OxBZ	OxBZ+hexose+H^a			OxBZ+hexose+H^a

Trace amounts.