Table 2.
Sub-set of genes significantly (adjusted p values < 0.01) up-regulated greater than 2 fold, followed by their log2 fold change for C. elegans CB3474 ben-1(e1880)III exposed to 1.13 mM BZ for 4 h in response to all benzimidazoles tested.
| Gene ID | Putavie enzyme | Gene description | ABZ Δ log2 fold | FBZ Δ log2 fold | MBZ Δ log2 fold | OxBZ Δ log2 fold | TBZ Δ log2 fold |
|---|---|---|---|---|---|---|---|
| alh-5 | Phase I | Aldehyde dehydrogenase | 2.25 | 1.64 | 1.25 | 1.28 | 1.74 |
| dhs-23 | Phase I | DeHydrogenases, Short chain | 3.28 | 3.76 | 2.82 | 8.20 | 3.90 |
| E02C12.10 | Phase I | Uncharacterized oxidoreductase Dhs-27 | 7.20 | 12.83 | 6.38 | 15.47 | 8.33 |
| C52A10.2 | Phase I | Carboxylic ester hydrolase | 3.00 | 5.43 | 4.27 | 6.96 | 2.19 |
| F13H6.3 | Phase I | Esterase CM06B1 | 2.35 | 2.15 | 2.74 | 4.07 | 1.27 |
| gba-2 | Phase I | Putative glucosylceramidase 2 | 4.28 | 6.95 | 3.34 | 7.60 | 5.53 |
| Y73C8C.10 | Phase I | FMN binding activity and oxidoreductase activity | 5.73 | 5.54 | 4.48 | 7.40 | 5.83 |
| T25G12.13 | Phase I | ortholoug of dhrs7b (dehydrogenase/reductase(SDR family) | 5.91 | 7.07 | 5.09 | 9.62 | 7.20 |
| T10B5.8 | Phase I | predicted FMN binding and oxidoreductase activity | 2.96 | 1.95 | 1.62 | 5.33 | 4.16 |
| cyp-13A6 | Phase I | CYtochrome P450 family | 2.16 | 4.93 | 8.83 | 6.92 | 2.02 |
| cyp-14A4 | Phase I | CYtochrome P450 family | 2.26 | 3.03 | 3.47 | 8.14 | 1.78 |
| cyp-34A9 | Phase I | CYtochrome P450 family | 1.60 | 3.05 | 3.94 | 3.81 | 1.36 |
| cyp-35A1 | Phase I | CYtochrome P450 family | 8.61 | 7.53 | 6.79 | 9.63 | 6.06 |
| cyp-35A2 | Phase I | CYtochrome P450 family | 5.00 | 3.72 | 3.93 | 2.97 | 1.54 |
| cyp-35A3 | Phase I | CYtochrome P450 family | 6.06 | 7.44 | 4.97 | 8.25 | 7.61 |
| cyp-35A4 | Phase I | CYtochrome P450 family | 5.26 | 5.63 | 5.46 | 6.52 | 5.88 |
| cyp-35A5 | Phase I | CYtochrome P450 family | 7.11 | 6.40 | 5.88 | 7.10 | 7.67 |
| cyp-35B2 | Phase I | CYtochrome P450 family | 4.37 | 4.96 | 2.91 | 7.04 | 3.80 |
| cyp-35C1 | Phase I | CYtochrome P450 family | 7.18 | 5.45 | 5.61 | 5.55 | 3.24 |
| ugt-8 | Phase II | UDP-GlucuronosylTransferase | 5.26 | 3.91 | 3.42 | 5.69 | 4.73 |
| ugt-9 | Phase II | UDP-GlucuronosylTransferase | 4.32 | 4.53 | 3.56 | 6.90 | 4.54 |
| ugt-14 | Phase II | UDP-GlucuronosylTransferase | 3.41 | 2.52 | 2.56 | 4.29 | 2.26 |
| ugt-25 | Phase II | UDP-glucuronosylTransferase | 3.02 | 1.27 | 2.08 | 3.73 | 1.94 |
| ugt-33 | Phase II | UDP-GlucuronosylTransferase | 3.50 | 5.49 | 2.44 | 9.24 | 2.76 |
| ugt-34 | Phase II | UDP-GlucuronosylTransferase | 5.41 | 5.76 | 3.06 | 6.99 | 4.62 |
| ugt-37 | Phase II | UDP-GlucuronosylTransferase | 1.68 | 4.09 | 2.09 | 3.39 | 3.32 |
| ugt-41 | Phase II | UDP-GlucuronosylTransferase | 1.89 | 1.61 | 1.54 | 3.38 | 1.30 |
| gst-5 | Phase II | Probable glutathione S-transferase 5 | 2.29 | 3.18 | 2.24 | 4.42 | 1.93 |
| gst-21 | Phase II | Glutathione S-Transferase | 1.73 | 2.08 | 1.35 | 5.89 | 2.15 |
| C29F7.2 | Phase II | Predicted transferase, transfers phophorous-cantaining groups | 4.10 | 4.09 | 2.87 | 4.07 | 2.25 |
| H23N18.4 | Phase II | Predicted transferase, transfers hexosyl groups | 5.83 | 7.02 | 4.19 | 7.33 | 7.16 |
| nhr-142 | Nuclear Hormone Receptor family | 1.29 | 1.65 | 1.23 | 2.79 | 1.44 | |
| apy-1 | Apyrase, guanosine and uridine-diphosphatase | 1.17 | 1.47 | 1.85 | 2.67 | 1.19 | |
| cdr-1 | CaDmium Responsive; Cadmium-inducible lysosomal protein CDR-1 | 4.26 | 5.24 | 8.76 | 8.19 | 10.37 | |
| irg-2 | Infection Response protein | 2.88 | 3.69 | 3.03 | 6.23 | 1.50 | |
| clec-206 | C-type LECtin | 6.47 | 5.70 | 5.91 | 7.44 | 6.43 | |
| ptr-22 | PaTched Related family | 5.16 | 4.37 | 3.66 | 4.75 | 3.99 | |
| F54B8.4 | death domain binding activity; involved in innate immune response | 1.62 | 1.33 | 1.52 | 2.56 | 1.53 | |
| vem-1 | ortholog of PGRMC1; is involved in innate immune response | 2.52 | 2.86 | 2.06 | 3.73 | 1.59 | |
| Y102A11A.9 | Uncharacterized, up-regulated in response to chemicals | 1.68 | 2.82 | 1.98 | 3.19 | 1.39 | |
| R09E12.9 | Uncharacterized, up-regulated in response to chemicals | 5.29 | 5.56 | 3.37 | 7.50 | 6.73 | |