Table 3.
Summary of Complete Gene Ontology (GO Slim) biological process analysis of the C. elegans CB3474 ben-1(e1880)III for differentially expressed genes, significantly up-regulated greater than 2-fold using Panther Overrepresentation Test (release 20190711) with FDR correction. Cut off for GO terms selected for this table: fold enrichment of > 4.5 fold.
| PANTHER GO-Slim Biological Process | C. elegans REFLIST (19921) | Input | Expected | over/ under | Fold Enrichment | P-value |
|---|---|---|---|---|---|---|
| ABZ | ||||||
| response to xenobiotic stimulus (GO:0009410) | 40 | 12 | 0.39 | + | 31.13 | 6.0E-14 |
| response to drug (GO:0042493) | 58 | 12 | 0.56 | + | 21.47 | 2.7E-12 |
| organic acid metabolic process (GO:0006082) | 76 | 12 | 0.73 | + | 16.38 | 4.4E-11 |
| cellular catabolic process (GO:0044248) | 91 | 12 | 0.88 | + | 13.68 | 2.9E-10 |
| drug metabolic process (GO:0017144) | 91 | 12 | 0.88 | + | 13.68 | 2.9E-10 |
| innate immune response (GO:0045087) | 120 | 13 | 1.16 | + | 11.24 | 4.8E-10 |
| cellular response to chemical stimulus (GO:0070887) | 112 | 12 | 1.08 | + | 11.12 | 2.5E-09 |
| defense response (GO:0006952) | 123 | 13 | 1.19 | + | 10.97 | 6.3E-10 |
| response to stress (GO:0006950) | 212 | 14 | 2.04 | + | 6.85 | 3.8E-08 |
| response to chemical (GO:0042221) | 187 | 12 | 1.8 | + | 6.66 | 4.9E-07 |
| MBZ | ||||||
| response to xenobiotic stimulus (GO:0009410) | 40 | 17 | 0.3 | + | 57.21 | 2.4E-23 |
| response to drug (GO:0042493) | 58 | 17 | 0.43 | + | 39.45 | 4.5E-21 |
| organic acid metabolic process (GO:0006082) | 76 | 17 | 0.56 | + | 30.11 | 2.4E-19 |
| cellular catabolic process (GO:0044248) | 91 | 17 | 0.68 | + | 25.15 | 3.4E-18 |
| drug metabolic process (GO:0017144) | 91 | 17 | 0.68 | + | 25.15 | 3.4E-18 |
| cellular response to chemical stimulus (GO:0070887) | 112 | 19 | 0.83 | + | 22.83 | 1.6E-19 |
| response to chemical (GO:0042221) | 187 | 20 | 1.39 | + | 14.4 | 6.3E-17 |
| response to stimulus (GO:0050896) | 627 | 23 | 4.66 | + | 4.94 | 4.4E-10 |
| TBZ | ||||||
| response to xenobiotic stimulus (GO:0009410) | 40 | 12 | 0.6 | + | 19.92 | 1.1E-11 |
| response to drug (GO:0042493) | 58 | 12 | 0.87 | + | 13.74 | 4.5E-10 |
| organic acid metabolic process (GO:0006082) | 76 | 12 | 1.14 | + | 10.48 | 6.9E-09 |
| cellular response to chemical stimulus (GO:0070887) | 112 | 16 | 1.69 | + | 9.49 | 7.8E-11 |
| cellular catabolic process (GO:0044248) | 91 | 12 | 1.37 | + | 8.76 | 4.2E-08 |
| drug metabolic process (GO:0017144) | 91 | 12 | 1.37 | + | 8.76 | 4.2E-08 |
| innate immune response (GO:0045087) | 120 | 13 | 1.81 | + | 7.19 | 9.5E-08 |
| defense response (GO:0006952) | 123 | 13 | 1.85 | + | 7.02 | 1.2E-07 |
| response to chemical (GO:0042221) | 187 | 19 | 2.82 | + | 6.75 | 2.7E-10 |
| OxBZ | ||||||
| response to xenobiotic stimulus (GO:0009410) | 40 | 24 | 1 | + | 24.1 | 1.1E-22 |
| response to drug (GO:0042493) | 58 | 24 | 1.44 | + | 16.62 | 9.1E-20 |
| organic acid metabolic process (GO:0006082) | 76 | 24 | 1.89 | + | 12.68 | 1.5E-17 |
| drug metabolic process (GO:0017144) | 91 | 25 | 2.27 | + | 11.03 | 5.0E-17 |
| cellular catabolic process (GO:0044248) | 91 | 24 | 2.27 | + | 10.59 | 4.6E-16 |
| cellular response to chemical stimulus (GO:0070887) | 112 | 28 | 2.79 | + | 10.04 | 5.3E-18 |
| response to chemical (GO:0042221) | 187 | 29 | 4.66 | + | 6.23 | 8.0E-14 |
| FBZ | ||||||
| intraciliary transport (GO:0042073) | 11 | 11 | 1.23 | + | 8.94 | 2.6E-06 |
| regulation of trans-synaptic signaling (GO:0099177) | 14 | 11 | 1.57 | + | 7.02 | 1.2E-05 |
| modulation chemical synaptic transmission (GO:0050804) | 14 | 11 | 1.57 | + | 7.02 | 1.2E-05 |
| cell surface receptor signaling pathway (GO:1905114) | 9 | 7 | 1.01 | + | 6.95 | 5.2E-04 |
| glutamate receptor signaling pathway (GO:0007215) | 8 | 6 | 0.9 | + | 6.7 | 1.5E-03 |
| regulation of signaling (GO:0023051) | 15 | 11 | 1.68 | + | 6.55 | 1.9E-05 |
| synaptic transmission, glutamatergic (GO:0035249) | 15 | 11 | 1.68 | + | 6.55 | 1.9E-05 |
| cilium organization (GO:0044782) | 30 | 20 | 3.36 | + | 5.96 | 2.5E-08 |
| protein localization to cilium (GO:0061512) | 28 | 16 | 3.13 | + | 5.11 | 2.8E-06 |
| response to xenobiotic stimulus (GO:0009410) | 40 | 22 | 4.48 | + | 4.92 | 6.6E-08 |
| cAMP-mediated signaling (GO:0019933) | 25 | 13 | 2.8 | + | 4.65 | 5.1E-05 |