Table 1.

Antibacterial activities of lFVII, polymyxin B and meropenem against a range of Gram-negative bacteria

Bacterial type	Code/name	lFVII (nM)		Polymyxin B (nM)		Meropenem (nM)
		MHB	TBS	MHB	TBS	MHB	TBS
A. baumannii	ATCC 19606	462.49 ± 66.55	10.23 ± 2.22	422.57 + 115.25	1843.94 ± 76.83	453.70 ± 3.43	>450,000
K. peneumoniae	ATCC 4352	409.63 ± 34.01	9.84 ± 3.44	514.77 + 184.39	1690.28 ± 153.66	460.56 ± 19.43	>450,000
P. aeruginosa	ATCC 27853	411.46 ± 13.93	15.26 ± 4.41	457.14 + 157.50	3726.30 ± 268.91	811.41 ± 102.85	>450,000
E. cloacae	Y1	449.01 ± 37.59	12.59 ± 0.17	414.89 + 107.56	1613.45 ± 76.83	342.85 ± 114.28	>450,000
P. aeruginosa	PA3 (XDR)	449.01 ± 37.59	12.59 ± 0.17	418.73 ± 119.09	2185.84 ± 733.73	NT	NT
P. aeruginosa	PA4 (XDR)	528.27 ± 164.03	12.00 ± 0.19	422.57 ± 107.56	2381.76 ± 845.14	NT	NT
A. baumannii	Ab3 (XDR)	373.01 ± 21.87	4.27 ± 1.38	145.98 ± 53.78	1759.43 ± 145.98	NT	NT
A. baumannii	Ab5 (XDR)	874.06 ± 16.33	7.67 ± 2.82	276.59 ± 46.10	3518.85 ± 215.13	NT	NT
A. baumannii	Ab16 (XDR)	363.38 ± 3.72	3.25 ± 0.33	145.98 ± 46.10	1805.53 ± 268.91	NT	NT
A. baumannii	Ab18 (XDR)	375.23 ± 2.62	4.66 ± 1.58	145.98 ± 38.42	1567.35 ± 84.51	NT	NT
A. baumannii	Ab30 (XDR)	413.65 ± 41.20	5.13 ± 2.00	138.30 ± 30.73	1982.24 ± 61.46	NT	NT
A. baumannii	Ab35 (XDR)	374.03 ± 10.54	5.00 ± 1.91	149.05 ± 4.61	1528.93 ± 69.15	NT	NT
A. baumannii	Ab42 (XDR)	401.26 ± 43.51	4.01 ± 0.95	142.14 ± 34.57	1759.43 ± 7.68	NT	NT
A. baumannii	Ab46 (XDR)	377.36 ± 4.72	3.49 ± 0.55	130.61 ± 53.78	1882.36 ± 345.74	NT	NT
A. baumannii	Ab48 (XDR)	365.30 ± 5.52	3.35 ± 0.32	130.61 ± 46.10	2593.04 ± 1018.01	NT	NT

The MBC value is defined as the minimum drug concentration that causes quantitative bacterial cell death; further details are provided in Materials and Methods. All data are expressed as means ± SD (n = 4); NT, not tested. Bacteria with ATCC code were obtained from American Type Culture Collection; the other tested bacteria are clinical isolates obtained from a hospital in Sichuan, China