Fig. 4.

Anti-SFTSV effect of benidipine hydrochloride and nifedipine in mouse models. a, b Spleen (a) or serum (b) viral loads in SFTSV-infected C57BL/6 mice (five for each group) treated with benidipine hydrochloride, nifedipine, or vehicle (0.3% carboxymethyl cellulose solution), were measured by qRT-PCR at 1, 3, 5, and 7 dpi. c Serum viral loads in SFTSV-infected humanized mice treated with benidipine hydrochloride (n = 6), nifedipine (n = 6), or vehicle (0.3% carboxymethyl cellulose solution) (n = 7), were measured by qRT-PCR at 1, 3, 5, 7, 9, 13, and 17 dpi. d Analysis of benidipine hydrochloride and nifedipine treatment on survival probability in humanized mice. The Kaplan–Meier method was used to analyze time-to-event data. The mean value of each group (a–c) was indicated by horizontal line. The significance of the difference between mean values was determined by Student’s t-test. P values < 0.05 were indicated for each comparison