Fig. 5.
Clinical effect analysis of nifedipine treatment on SFTS-related fatality and clearance of SFTSV. a Flowcharts of recruitment and grouping of SFTS patients. A total of 2087 patients who had been admitted into the sentinel hospital for SFTS, were included in the retrospective clinical investigation that was performed to evaluate the clinical effect of nifedipine in treating SFTS. By thoroughly reviewing the medical records of these patients, 83 nifedipine-treated, 48 non-nifedipine-treated, and 249 general SFTS patients, were included for comparison. CCBs, calcium channel blocks. b Analysis of nifedipine treatment on survival probability. The Kaplan-Meier method was used to analyze time-to-event data. NT, the number of nifedipine-treated patients; NG, the number of general SFTS patients; NN, the number of non-nifedipine-treated patients. c Analysis of nifedipine treatment effect on the viral loads in SFTS patients. The GEE model was used to analyze sequentially tested viral loads during hospitalization; statistical analysis results were presented in Supplementary information, Table S7. The circle indicates mean value and the dashed line indicates standard deviation. d Analysis of nifedipine treatment effect on the viral clearance in SFTS patients. χ2 test was used to compare the frequency difference between two groups, and P values < 0.05 were shown. The circle indicates frequency and the dashed line indicates 95% CI. NT indicates number of patients in nifedipine-treated group, NG indicates number of patients in general SFTS group, and NN indicates number of patients in non-nifedipine group