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ChT-L activity of the latent 20S proteasome, probed with the substrate Suc-LLVY-AMC, was strongly and diversely regulated by PR peptides. At low concentrations 6, 11, and 12 transiently activated the proteasome. 1 and 2 proved to be strong activators of the latent CP and induced typical sigmoidal dose response stimulation. The results are presented as the mean ± SEM.
