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. 2018 Nov 19;62(1):359–370. doi: 10.1021/acs.jmedchem.8b01025

Table 2. Kinetic Parameters of Inhibition of SDS-Activated h20S Proteasome.

  compound 4
compound 7
kinetic parameter value SEM value SEM
Vmax [s–1] 13.46 0.91 13.64 0.88
KM [μM] 14.02 5.55 17.42 5.79
Ki [μM] 0.0101 0.0055 0.0048 0.0026
β 4.98 × 106 4.20 × 108 1347 1370
α 180878 7.65 × 106 4620 2963