Table 2. Kinetic Parameters of Inhibition of SDS-Activated h20S Proteasome.
compound 4 |
compound 7 |
|||
---|---|---|---|---|
kinetic parameter | value | SEM | value | SEM |
Vmax [s–1] | 13.46 | 0.91 | 13.64 | 0.88 |
KM [μM] | 14.02 | 5.55 | 17.42 | 5.79 |
Ki [μM] | 0.0101 | 0.0055 | 0.0048 | 0.0026 |
β | 4.98 × 106 | 4.20 × 108 | 1347 | 1370 |
α | 180878 | 7.65 × 106 | 4620 | 2963 |