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Overlay of homology model of FBD from TcdBUK1 with the crystal structure of TcdBVPI (PDB code: 6C0B) in two different views (A, side view; B, front view). The toxin and the cysteine-rich domain 2 (CRD2) from FZD2 are represented in brown and green, respectively. Key positive allosteric modulator (PAM) (silver) binding residues from the toxin (brown) and CRD2 (green) are shown as stick models. The FBD sequence from TcdBM68 is identical to that from TcdBVPI.
