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. 2019 Oct 16;4(5):e00580-19. doi: 10.1128/mSphere.00580-19

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Copyright © 2019 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — The structural domains (PAZ and PIWI) of three EhAgo proteins in E. histolytica. The length of proteins is drawn to scale, with the length of PAZ and PIWI based on the annotation of AmoebaDB. We generated EhAgo polyclonal antibodies in rabbits using peptide from the N-terminal end of sequence as indicated by Y* (see also Materials and Methods). The PAZ Superfam domain (SSF101690) is shown in orange, and the PAZ Pfam (PF02170) domain of EhAgo2-1 and EhAgo2-2 is shown in green. The PIWI Pfam (PF02171) domain is in blue. Specific PAZ/PIWI mutations generated in this study are shown. Both EhAgo2-1 and EhAgo2-2 have ∼200 aa after the PIWI domain, with an RGG/RG motif (red) and repetitive DR-rich region (gray) identified in EhAgo2-2.