Fig. 1. Mutation of the conserved adenine residue of a splice acceptor using an ABE results in exon skipping.

a Diagram of the consensus sequence of splice acceptor sites. Mutation of the conserved adenosine residue (*) prevents recognition by the splice machinery which leads to skipping of the exon. b ABEs can be directed to the splice acceptor site to convert the target A to a G, which results in exon skipping