Fig. 4. Quantification of genomic DNA mutation rates created by several ABE constructs at multiple target sites.

High-throughput sequencing was used to quantify rates of A > G genomic DNA mutation and rates of exon skipping across multiple targets using several ABE variants. * and ** correspond to P < 0.05 and P < 0.01, respectively by two-tailed unpaired Student’s t test across two biological replicates