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Risk score of obesity-driven biomarkers predicts ccRCC risk in (A) discovery, (B) validation and (C) combined populations. In combined population, the fourth (Q4), third (Q3) and second (Q2) quartile subgroups demonstrated significant increased cancer risk (3.04-fold, 2.33-fold and 1.94-fold) compared with first quartile (Q1) subgroup of risk score (P for trend = 2.18E-13) using multivariable logistic regression model adjusted by age, gender, smoking, BMI, diabetes and hypertension.
