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. 2019 Sep-Oct;116(5):347–350.

Table 1.

Pharmacologic Recommendations for Post-Operative Dental Pain

Pain Severity Therapeutic Intervention
Mild Ibuprofen 200–400 mg q 4–6 hours
Mild to Moderate Ibuprofen 400–600 mg q 6 hours for 24 hours
Ibuprofen 400 mg q 4–6 prn pain on POD #1 (after first 24 hours)
Moderate to Severe Ibuprofen 400–600 mg with APAP 500 mg q 6 hours for 24 hours.
Ibuprofen 400 mg with APAP 500 mg q 6 hours on POD #1 (after first 24 hours)
Severe Ibuprofen 400–600 mg with APAP 650 mg and Hydrocodone 5 mg q 6 hours for 3 days;
then
Ibuprofen 400–600 mg with APAP 500 mg q 6 hours on POD #4 (after first 72 hours).
If NSAIDs are contraindicated
Mild APAP 650–1000 mg q 6 hours for pain
Moderate APAP 650–1000 mg with hydrocodone 5 mg q 6 hours for 3 days; then
APAP 650–1000 mg q 4–6 hours (after first 72 hours)
Severe APAP 650 mg with hydrocodone 5 mg q 6 hours for 3 days, then
APAP 650–1000 mg q 6 hours (after first 72 hours)

APAP acetaminophen (Tylenol)

Ibuprofen maximum daily dose is 2400 mg

APAP maximum daily dose is 3000 mg

Adapted from References: 4,7,11,13,14