Table 2.

Common Terminology Criteria for Adverse Events v5.0 Criteria for Fibrosis Defined as “A Disorder Characterized by Fibrotic Degeneration of the Connective Tissues”

Grade	Descriptor
1	Mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up)
2	Moderate induration, able to slide skin, unable to pinch skin, or limiting instrumental ADL
3	Severe induration, unable to slide or pinch skin, or limiting joint or orifice movement (e.g., mouth, anus), or limiting self-care ADL