Table 1. Characterization of the loops of the G domain.

(Motif-)Loop	Sequence	Key residuesa	Flexibility
			clusters	populationb	RMSDc
G1-P	44–52	K48, K51	23	89.6%	7.7 Å
G2-SW1	58–77	S73, T75	259	40.5%	15.5 Å
G3-SW2	98–110	E99	175	50.6%	14.5 Å
L1	149–172		115	42.4%	9.5 Å
G4-L2	181–198	D184	194	37.1%	13.4 Å
GC	235–261	R240, R244, D255	675	26.4%	22.0 Å

^a Residues which are important for GTP binding, hydrolysis or hGBP1 dimerization.

^b Percentage of the structures which are cumulatively represented by the first three clusters.

^c The largest RMSD found between two loop conformations.