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. 2019 Sep 23;6(1):e000440. doi: 10.1136/bmjresp-2019-000440

Figure 1.

Figure 1

Intrapleural administration of t-PA and DNase increases the volume of output pleural fluid (PF). (A) Daily output of PF volume in mL for each randomisation arm of the MIST2 study: t-PA and DNase, t-PA and placebo, DNase and placebo and double placebo. during treatment period (days 1–3) groups receiving t-PA±DNase demonstrated increased volume of drained pleural fluid compared with non-t-PA receiving groups for the same period and all groups for post-treatment period (days 5–7). Data are presented as mean±95% CI. (B) Output of PF volume in mL for each randomisation arm during treatment period (days 1–3). The groups that received t-PA alone or t-PA and DNase exhibited increased volume of drained PF. Data are presented as mean±95% CI. ***Denotes p<0.001 for the indicated comparisons by one-way ANOVA with Tukey’s post-tests. (C) Output of PF volume in mL for each randomisation arm during post-treatment period (days 5–7). No statistical significant differences were found between groups by one-way ANOVA with Tukey’s post-tests. Data are presented as mean±95% CI. (D) Output of PF volume in mL for the groups that received t-PA and DNase and t-PA and placebo during the treatment and post-treatment periods. While treatment was ongoing, patients receiving intrapleural t-PA exhibited higher volume of drained PF compared with the post-treatment period. Data are presented as mean±95% CI. ***Denotes p<0.001 for the indicated comparisons by one-way ANOVA with Tukey’s post hoc tests. ANOVA, analysis of variance; t-PA, tissue plasminogen activator.