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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Cancer Res. 2019 Sep 3;79(20):5159–5166. doi: 10.1158/0008-5472.CAN-19-0647

Figure 2. Homozygous or heterozygous deletion of Atmin or Atm increases LUAD tumor burden.

Figure 2

A) Schematic representation of the genetic alleles and experimental strategy used.

B) Representative images of H&E sections (left) and dot plot (right) quantifying the tumor burden in lungs isolated from mice of the indicated genotypes. Scale bar, 1000 μm. Dots represent individual mice; red horizontal line indicates mean. P values calculated using Mann-Whitney U non-parametric test.

C) Quantification of lung lesions according to tumor grade in mice of the indicated genotypes. At least 200 lung lesions from 5 different mice per genotype were analyzed. Values are mean + SEM.

D) Quantification of Ki-67 staining on lung tumors from mice of the indicated genotypes. At least 30 tumors from 3 mice per genotype were quantified. Bar chart shows mean + SEM. P values calculated using Mann-Whitney U non-parametric test.