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Low RND3 expression leads to activation of NF‐κB signalling and apoptosis resistance in GBM cells. High levels of RND3 in cells bind to p65, promote ubiquitination of p65 protein and inhibit NF‐κB signalling activity, whereas low expression of RND3 in cells results in reduced binding of RND3 to p65, which decreases ubiquitination of p65 protein and promotes activation of NF‐κB signalling, leading to apoptosis resistance in GBM cells
