FIGURE 7.

Prenatal LPS exposure increases spine density in apical but not basal dendrites of CA1 pyramidal neurons, a response based on the activation of Cx43 hemichannels. (A,B) Representative golgi (black) staining by apical dendrites of CA1 pyramidal neurons from control offspring (A) or prenatally LPS-exposed offspring of 4 months old (B). (C,D) Averaged data of the number of apical (A) or basal (B) dendritic spines by CA1 pyramidal neurons from control offspring (white bars) or prenatally LPS-exposed offspring of 4 months old alone (black bars) or in combination with the in vivo administration of 23 mg/kg Tat-gap19 (gray bars). ^∗p < 0.05 versus LPS, one-way ANOVA Tukey’s post hoc test, mean ± S.E.M., n = 3. Calibration bar = 3 μm.