Figure 6.

14‐3‐3ζ depletion retarded tumour growth in mouse xenograft. Hep‐2 cells transfected with control or 14‐3‐3ζ siRNA for 48 h and then injected into nude mice. A, Tumour weight in each group xenograft mice was measured at 2 weeks after injection. The weight range was indicated as graph (right, n = 5, P = 0.08). B, Levels of 14‐3‐3ζ and p27 were examined by immunohistochemistry. Representative images are shown at left panels, and the quantitation results were provided as integrated optical intensities (IOD, right panels). *P < 0.05. Scale bar, 100 μm. C, A proposed model for the molecular axis which is involved in the senescence induction by 14‐3‐3ζ silencing