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. 2019 Oct 11;10:977. doi: 10.3389/fgene.2019.00977

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Copyright © 2019 Marín-Llera, Garciadiego-Cázares and Chimal-Monroy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Signalling centres controls limb development. (A) A posterior view of a scanning electron microscopy of a 22HH chicken hindlimb bud showing in blue the apical ectodermal ridge (AER) between the dorsal and ventral ectoderm. The localization of the zone of polarizing activity (ZPA) is showed with an asterisk. (B) In situ hybridization in a 22HH chicken hindlimb showing the expression of Shh in the ZPA and Fgf8 in the AER, signalling centres of the limb bud.