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. 2019 Oct 11;10:977. doi: 10.3389/fgene.2019.00977

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Copyright © 2019 Marín-Llera, Garciadiego-Cázares and Chimal-Monroy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synovial joint formation. (A) 31HH chick hindlimb showing an in situ hybridization for Gdf5. (B) Alcian blue staining of a developing digit of a turtle embryo. Notice lack of staining in the interphalangeal zone (arrowhead). (C) An early developing joint stained with Safranin O of a E13.5 mouse embryo showing the interzone (asterisk). Subpopulations from this area give rise to the different tissues of the joint. (D) A sagittal section of a knee-joint of a newborn mouse stained with phalloidin showing the different tissues of the joint; articular cartilage (ac), cruciate ligaments (cl), cells that will give rise to the infrapatellar pad (ip), patella (p), and patellar ligament (pl). Joint cavity is indicated with an asterisk.