Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 11;10:977. doi: 10.3389/fgene.2019.00977

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Marín-Llera, Garciadiego-Cázares and Chimal-Monroy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Skeletal stem cells during endochondral ossification. (A) Longitudinal section of an E18.5 mouse tibia stained with Safranin O. Zone I, zone II, and the zone of hypertrophic chondrocytes are represented. Zone I corresponds to the entire epiphysis and contains differentiated chondrocytes that in this stage are all proliferative and originates the articular cartilage. Zone II corresponds to cells, originated from zone I, organized in parallel columns. (B) Growth plate of 6-weeks-old rat. In the juvenile stage, chondrocytes from the resting zone (arrowheads) behave as stem cells giving rise to different clones disposed in a column, that contributes to the longitudinal growth of the skeletal elements. In foetal, neonatal, and juvenile stages columns extend up to the primary spongiosa (ps).