Figure 1.

Platelet receptors for the detection of bacterial pathogens in the bloodstream. Platelets are equipped with a diverse array of surface and intracellular receptors for pathogen detection, enabling their function as intravascular sentinel cells. These include receptors for the detection of bacterial produces and molecules (TLRs, NLRs, C-type lectins, integrins, GP1bα), as well as bacteria that have been coated by antibody (Fc recpetors), complement (complement receptors), or von Willibrand factor (integrins and GP1bα).