Table 2.
List of differentiating metabolites with their serum concentrations determined in the studied groups (mean ± SD, µM) and results from univariate statistics
| Metabolite | Abbreviation | Lung cancer group1 | Control group1 | p value2 | FDR3 | Fold change4 | AUC (95% CI) |
|---|---|---|---|---|---|---|---|
| Lysophosphatidylcholine acyl C26:0 | lysoPC a C26:0 | 0.53 ± 0.14 | 0.31 ± 0.14 | 0.00011 | 0.01113 | 1.71 | 0.87 (0.73–0.96) |
| Lysophosphatidylcholine acyl C26:1 | lysoPC a C26:1 | 0.28 ± 0.07 | 0.18 ± 0.06 | 0.00083 | 0.04337 | 1.52 | 0.84 (0.68–0.95) |
| Phosphatidylcholine diacyl C34:4 | PC aa C34:4 | 0.93 ± 0.40 | 1.44 ± 0.43 | 0.00162 | 0.04529 | 0.65 | 0.82 (0.65–0.94) |
| Phosphatidylcholine diacyl C42:4 | PC aa C42:4 | 0.46 ± 0.22 | 0.26 ± 0.12 | 0.00174 | 0.04529 | 1.79 | 0.81 (0.65–0.93) |
| Phosphatidylcholine acyl–alkyl C42:1 | PC ae C42:1 | 0.69 ± 0.14 | 0.53 ± 0.13 | 0.00273 | 0.04729 | 1.57 | 0.80 (0.64–0.94) |
| Phosphatidylcholine acyl–alkyl C44:3 | PC ae C44:3 | 0.52 ± 0.21 | 0.33 ± 0.11 | 0.00322 | 0.04789 | 1.58 | 0.80 (0.62–0.92) |
| Phosphatidylcholine diacyl C40:2 | PC aa C40:2 | 0.24 ± 0.09 | 0.15 ± 0.04 | 0.00381 | 0.04904 | 1.88 | 0.80 (0.64–0.92) |
1Values calculated from combined discovery and validation set
2Raw p value from Wilcoxon rank-sum test
3False discovery rate
4Calculated from the mean values of each group; comparison type: lung cancer group/control group