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. 2019 Aug 6;178(2):263–274. doi: 10.1007/s10549-019-05380-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Synergistic effect of AEE788 and rapalogs on proliferative inhibition and cell death in rapalog-resistant TNBC cells. a Proliferative response of rapalog-resistant SUM149PT (left panel) and HCC1143 (right panel) TNBC cells, to rapalogs Rap, Tem, and Eve in concentration range alone or combined with 0.316 µM and 1 µM AEE788, respectively. b IC50 values (µM) of rapalogs in combination with AEE788, inducing 50% of proliferation inhibition in SUM149PT and HCC1143 cells. c Combination index (CI) of rapalog and AEE788 in SUM149PT and HCC1143 cells. CI < 1 indicates synergism. d, e Combinatorial effects of Rap and AEE788 on SUM149PT (left panel, d) and HCC1143 (right panel, e) cell death. Cells were subjected to Annexin V/Propidium Iodide (AnV/PI) apoptosis assays after treatment for 24, 48, 72, and 96 h. Cisplatin (100 µM) was used as positive control. (two-way ANOVA *p < 0.05, **p < 0.01, ***p < 0.001)