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. 2019 Aug 6;178(2):263–274. doi: 10.1007/s10549-019-05380-z

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Validation of AEE788 potential targets synergizing with rapamycin in rapalog-resistant TNBC cells. a Radar chart displaying highly predicted targets of AEE788 in ChEMBL_23 database with 1 µM (blue) and 10 µM (red) as cutoff. b Screen of AEE788 targets with siRNA alone (siRNA) or in combination with 0.01 µM rapamycin (siRNA + Rap) in SUM149PT cells. siCtrl, siRNA control. c siRNA silencing effect of AEE788 targets synergizing with rapamycin. The ratio of percentages of proliferation was shown as FC (siRNA versus siRNA + Rap). Targets with silencing effect over siCtrl (FC > 1.7, blue) were marked in red. d Protein–protein interactions of AEE788 targets (red) by NetworkAnalyst. Proteins interacting with mTOR signaling pathway were marked in green