Table 4.
Joint model (n = 156) with 95% confidence interval
| Sub-model | Variable | Estimate (95% CI) | p-value |
|---|---|---|---|
| Longitudinal | Age of HAM-A Measurement | 0.039 (0.013, 0.065) | 0.003 |
| Female offspring | 0.249 (0.008, 0.489) | 0.043 | |
| Male offspring | * | – | |
| Lithium responder parent | − 0.262 (− 0.516, − 0.007) | 0.044 | |
| Lithium non-responder parent | * | – | |
| SES 123 | 0.372 (0.013, 0.731) | 0.106a | |
| SES 4 | 0.199 (− 0.070, 0.467) | ||
| SES 5 | * | ||
| Parent onset age | − 0.001 (− 0.014, 0.012) | 0.914 | |
| Age at initial interview | 0.023 (− 0.053, 0.007) | 0.128 | |
| Cox | Female offspring | 0.500 (− 0.269, 1.269) | 0.203 |
| Male offspring | * | – | |
| Lithium responder parent | 0.431 (− 0.398, 1.260) | 0.308 | |
| Lithium non-responder parent | * | – | |
| SES 123 | − 0.299 (− 1.444, 0.845) | 0.274a | |
| SES 4 | 0.392 (− 0.454, 1.238) | ||
| SES 5 | * | ||
| Parent onset age | − 0.006 (− 0.050, 0.038) | 0.797 | |
| Age at initial interview | − 0.115 (− 0.191, − 0.039) | 0.003 | |
| Estimated trajectory of logHAMA | 1.067 (0.258, 1.875) | 0.010 |
Italic values indicate significance of p-value (p < 0.05)
* = Reference level
ap-value obtained by a partial likelihood ratio test on 2 degrees of freedom; other p-values obtained by Wald tests